How does VSL#3 work?
VSL#3 acts as a protective barrier in the gastrointestinal (GI) tract. link VSL#3 works by colonizing the GI tract with optimal quantities and types of probiotic bacteria. These bacteria adhere to the walls of the GI tract and form a barrier that protects the inner layer of the gut from pathogens. The human GI tract has thousands of billions of resident bacteria called commensal bacteria. In order to change the composition of this gut flora in a positive way, an extremely large amount of probiotic bacteria is necessary. VSL#3 is the only probiotic preparation that delivers enough bacteria to beneficially affect the gut flora in patients with serious intestinal disorders.
VSL#3 bacteria make it all the way through the GI tract.
At the cellular level, VSL#3 positively affects a variety of substances that are involved in gut function. This is important to ensure the correct absorption of nutrients and to maintain barrier function.
Finally, evidence suggests that VSL#3 can reduce intestinal permeability by tightening the junctions between the cells in the outer layer of the intestine which reduces the likelihood of translocation (pathogens moving from the intestine into the blood).